Identifying the boundaries of skin tumors by differential backscatter

Abstract


The paper presents the experimental results of identifying the boundaries of skin tumors by differential backscatter. The differential coefficient of backscatter is proposed to be used as the threshold condition for identifying the boundary. The analysis of the skin of 27 patients showed that the ratio introduced makes it possible to identify the boundary of the tumors to within 1 mm with simultaneous identification of tumor types for pigmented nevi, epidermoid cancer and melanoma.


About the authors

V. P. Zakharov

Samara State Aerospace University

Author for correspondence.
Email: zakharov@ssau.ru

Russian Federation

Doctor of Physical and Mathematical Sciences, Professor

Head of the Department of Radio Engineering Devices

S. V. Kozlov

Samara State Medical University

Email: zakharov@ssau.ru

Russian Federation

Doctor of Medical Science

Head of the Oncology Department

E. V. Timchenko

Samara State Aerospace University

Email: vorobjeva.82@mail.ru

Russian Federation

Candidate of Physical and Mathematical Science

Associate Professor of the Department of Radio Engineering Devices

P. E. Timchenko

Samara State Aerospace University

Email: timpavel@mail.ru

Russian Federation

Candidate of Physical and Mathematical Science

Assistant of the Department of Radio Engineering Devices

A. A. Moryatov

Samara Regional Oncology Center

Email: zakharov@ssau.ru

Russian Federation

Candidate of Medical Science

Oncologist of the Department of Endoscopy

I. A. Bratchenko

Samara State Aerospace University

Email: zakharov@ssau.ru

Russian Federation

Candidate of Physical and Mathematical Science

Assistant of the Department of Radio Engineering Devices

L. A. Taskina

Samara State Aerospace University

Email: retuo@mail.ru

Russian Federation

Undergraduate Student

References

  1. Wang, L.V. Skin cancer detection by spectroscopic oblique-incidence reflectometry: classification and physiological origins [Text] / L.V. Wang // Appl. Opt. – 2004. – №43. – P. 2643-2650.
  2. Новик, А.В. Меланома кожи: новые подходы [Текст] / А.В. Новик // Практическая онкология. – 2011. – № 1 (12). – С. 36–42.
  3. Mogensen, M. Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: a review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologies [Text] / M. Mogensen, G. B. Jemec // Dermatol Surg. – 2007. – №33(10). – Р. 1158-1174.
  4. Salomatina, E. Optical properties of normal and cancerous human skin in the visible and nearinfrared spectral [Text] / E. Salomatina [et al.] // J. Biomed. Opt. – №11(6). – 2006. – 064026.
  5. Diebele, I. Analysis of skin basalioma and melanoma by multispectral imaging [Text] / I. Diebele [et al.] – Proc. of SPIE. – 2012. – Vol. 8427 842732–1.
  6. Захаров, В.П. Применение метода обратного дифференциального рассеяния для исследования биообъектов [Текст] / В.П. Захаров, П.Е. Тимченко, Р.В. Козлов, C.П. Котова, Е.В. Тимченко, В.В. Якуткин //Физика волновых процессов и радиотехнические системы. – 2008. – Т.11, №4. – С. 89–97.
  7. Hanlon, E.B. Prospects for in vivo Raman spectroscopy [Text] / E.B. Hanlon [et al.] // Phys. Med. Biol. – 2000. – №45. – R1-R59.
  8. Pohost, G.M. Магнитно-резонансная и рентген-компьютерная томографии при исследовании сердечно-сосудистой системы [Текст] / G.M. Pohost, D.J. Sarma, P.M. Colletti, M. Doyle // Основы кардиологии. Принципы и практика, 2005. – C. 295–323.
  9. Butte, P.V. Intraoperative delineration of primary brain tumors using time-resolved fluorescence spectroscopy [Text] / P.V. Butte, Q. Fang, J.A. Jo, W.H. Yong, B.K. Pikul, K.L. Black, and L. Marcu // J. Biomed. Opt. – 2010. – №15(2). – 027008.
  10. Butte, P.V. Diagnosis of meningioma by time resolved fluorescence spectroscopy [Text] / P.V. Butte, B.K. Pikul, A. Hever, W.H. Yong, K.L. Black, and L. Marcu // J. Biomed. Opt. – 2005. – №10(6). – 064026.
  11. Galletly, N.P. Fluorescence lifetime imaging distinguishes basal cell carcinoma from surrounding uninvolved skin [Text] / N.P. Galletly, J. Mcginty, C. Dunsby, F. Teixeira, J.Requejo-Isidro, I, Munro, D.S. Elson, M.A.A. Neil [et al.] // Br. J. Dermatol. – 2008. – №159(1) – P. 152–161.
  12. Mcginty, J. Wide-field fluorescence lifetime imaging of cancer [Text] / J. Mcginty, N.P. Galletly, C. Dunsby, I. Munro, D. S.Elson [et al.] // Biomed. Opt. Express. – 2010. – №1(2) – P. 627-640.
  13. Pradhan, A. Time-resolved UV photoexcited fluorescence kinetics from malignant and non-malignant breast tissues [Text] / A. Pradhan, B.B. Das, K.M. Yoo, R.R. Alfano, J. Cleary, R. Prudente, and E. Celmer // Proc. SPIE Conference. – 1992. – №1599. – P. 81-84.
  14. Wang, C.Y. Time-resolved autofluorescence spectroscopy for classifying normal and premalignant oral tissues [Text] / C.Y. Wang, H.M. Chen, C.P. Chiang, C. You, and T.C. Hsiao // Lasers Surg. Med. – 2005 – №37(1). – P. 37-45.
  15. Pfefer, T.J. Temporally and spectrally resolved fluorescence spectroscopy for the detection of high grade dysplasia in Barrett's esophagus [Text] / T.J. Pfefer, D.Y. Paithankar, J.M. Poneros, K.T. Schomacker, and N.S. Nishioka // Lasers Surg. Med. – 2003. – №32(1). – P. 10-16.
  16. Leppert, J. Multiphoton excitation of autofluorescence for microscopy of glioma tissue [Text] / J. Leppert, J. Krajewski, S.R. Kantelhardt, S. Schlaffer, N. Petkus, E. Reusche, G. Huttmann, and A. Giese // Neurosurgery. – 2006. – №58(4). – P. 759-767.
  17. Cicchi, R. Time- and Spectralresolved two-photon imaging of healthy bladder mucosa and carcinoma in situ [Text] / R. Cicchi, A. Crisci, A. Cosci, G. Nesi, D. Kapsokalyvas, S. Giancane, M. Carini, and F. S. Pavone // Opt. Express. – 2010. – №18(4). – Р. 3840-3849.
  18. Busam, K.J. Morphological features of melanocytes, pigmented keratinocytes and melanophages by in vivo confocal scanning laser microscopy [Text] / K. J. Busam, C. Charles, G. Lee, and A. C. Halpern // Mod. Pathol. – 2001. – №14(9). – №862–868.
  19. Bath-Hextall, F. Interventions for basal cell carcinoma of the skin: systematic review [Text] / F. Bath-Hextall, J. Bong, W. Perkins, and H. Williams // Br. Med. J. – 2004. – №329. – P. 704-713.
  20. Mogensen, M. Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: a review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologies [Text] / M. Mogensen and G.B.E. Jemec // Dermatol. Surg. – 2007. – №33. – P. 1146-1177.
  21. Krafft, C. Raman mapping and FTIR imaging of lung tissue: congenital cystic adenomatoid malformation [Text] / C. Krafft, D. Codrich, G. Pelizzo, and V. Sergo // Analyst (Cambridge, U.K.). – 2008. – №133. – P. 361-371.
  22. Keller, M. Raman spectroscopy for cancer diagnosis [Text] / M. Keller, E. M. Kanter, A. Mahadevan-Jansen // Spectroscopy, – 2006. – 21-11. – P. 33-41.
  23. Oshima, Y. Discrimination analysis of human lung cancer cells associated with his tological type and malignancy using Raman spectroscopy [Text] / Y. Oshima, H. Shinzawa, T. Furihata, H. Sato // Journal of Biomedical Optics. – 2010. – 15-20, – 017009 – (1-7).
  24. Dimou, G.Z.A. Melanin absorption spectroscopy: new method for noninvasive skin investigation and melanoma detection [Text] / G.Z.A. Dimou, I. Bassukas, D. Galaris, A.T.E. Kaxiras // Journal of Biomedical Optics – 2008. – №13(1), – 014017-(1-8).
  25. Волова, Л.Т. Оценка жизнеспособности клеток на бионосителе при помощи конфокальной микроскопии [Текст] / Л.Т. Волова, П.Е. Тимченко, Е.В. Тимченко, В.П. Захаров, В.В. Болтовская, М.А. Тертерян, В.В. Россинская // Морфологические ведомости. – 2011. – №3. – С. 22-27.

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