Increasing the information content of optical coherence tomography skin pathology detection

Cover Page

Cite item

Full Text

Abstract

A mathematical model of optical radiation interaction with skin tissues is constructed, which takes into account the effects of stimulated Raman scattering. On the basis of numerical experiments the features in the Raman scattering spectra are revealed to characterize skin abnormalities. The possibility of significant increase in information content for optical coherence tomography and Raman spectroscopy joint usage is shown. Recent improvement is achieved by significantly reducing the volume of diagnostic measurements during the tissue layers isolation with the help of OCT, followed by their analysis by Raman spectroscopy. Differences in Raman scattering intensities for abnormal and normal tissue layers are established, their values may differ by an amount of 40%.

About the authors

V. P. Zakharov

Samara State Aerospace University

Author for correspondence.
Email: zakharov@ssau.ru

Doctor of Physical and Mathematical Sciences

Professor

Head of the Radioengineering Devices Department

Russian Federation

K. Larin

University of Houston (USA)

Email: klarin@uh.edu

Professor

Director of Biomedical Optics Laboratory

United States

I. A. Bratchenko

Samara State Aerospace University

Email: ud_liche@mail.ru

Assistant of the Radioengineering Devices Department

Russian Federation

References

  1. Zawadzki, R. J. Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction [Текст] / R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, J. S. Werner // Optics Express. – 2008. – №16(11). – С. 8126 – 8143.
  2. Larina, I. V. Live imaging of rat embryos with Doppler swept-source optical coherence tomography [Текст] / I. V. Larina, K. Furushima, M. E. Dickinson, R. R. Behringer, K. V. Larin // J. Biomed. Opt. – 2009. –No. 14. – С. 505 – 506.
  3. Yoo, J. Increasing the field-of-view of dynamic cardiac OCT via post-acquisition mosaicing without affecting frame-rate or spatial resolution. [Текст] / J. Yoo, I. V. Larina, K. V. Larin, M. E. Dickinson, M. Liebling / Biomedical optics express. – 2009. – Vol. 2, – No. 9. – С. 2614 – 2622.
  4. Hitzenberg, C. Three- dimensional imaging of the human retina by high-speed optical coherence tomography [Текст] / C. Hitzenberger, P. Trost, Pak-Wai Lo, Q. Zhou // Optics Express. – 2003. – № 11(21). – С. 2753 – 2761.
  5. Sayanagi, K. Comparison of Retinal Thickness Measurements Between Three-dimensional and Radial Scans on Spectral-Domain Optical Coherence Tomography [Текст] / K. Sayanagi, S. Sharma, P. K. Kaiser // American Journal of Ophthalmology. – 2009. – № 148(3). – С. 431 – 438.
  6. Larin, K. V. Multiple-cardiac-cycle noise reduction in dynamic optical coherence tomography of the embryonic heart and vasculature [Текст] / S. Bhat, I. V. Larina, K. V. Larin, M. E. Dickinson, M. Liebling // OPTICS LETTERS. – 2009. – Vol. 34. -No. 23. – С. 3704 – 3706.
  7. Garvin, M. Intraretinal Layer Segmentation of Macular Optical Coherence Tomography Images Using Optimal 3-D Graph Search [Текст] / M. Garvin, M. Abr`amoff, R. Kardon, S. Russell, X. Wu, M. Sonka // IEEE Trans. Med. Imaging. – 2008. – No. 27(10). – С. 1495 – 1505.
  8. Mishra, A. Intra-retinal layer segmentation in optical coherence tomography images [Текст] / A. Mishra, A. Wong, K. Bizheva, D. A. Clausi // Optics Express. – 2009. – No. 17 (26). – С. 23719 – 23728.
  9. Gniadecka, M. Melanoma Diagnosis by Raman Spectroscopy and Neural Networks: Structure Alterations in Proteins and Lipids in Intact Cancer Tissue [Текст] / M. Gniadecka, P. A. Philipsen, S. r Sigurdsson, S. Wessel, O. F. Nielsen, D. Christensen, J. Hercogova, K. Rossen, H. Thomsen, R. Gniadecki, L.Hansen, H. C. Wulf // J Invest Dermatol. – 2004. – No. 122. – С. 443 – 449.
  10. Zhao, J. Real-time Raman spectroscopy for non-invasive skin cancer detection - preliminary results [Текст] / J Zhao, H, Lui // Conf Proc IEEE Eng Med Biol Soc. – 2008. – С. 3107 – 3109.
  11. Vermont, J. Fast fluorescence microscopy for imaging the dynamics of embryonic development [Текст] / J. Vermot, S. E. Fraser, and M. Liebling // HFSP J. – 2008. – No. 2. – С. 143 – 155.
  12. Захаров, В. П. 3D визуализация многократно рассеивающих сред [Текст] / В. П.Захаров, А. Р. Синдяева // Компьютерная оптика. – 2007. – Т.31. – №4. – С. 44 – 52.
  13. Захаров, В. П. Приближенный метод расчёта распределения энергии оптического излучения в многократно рассеивающих средах [Текст] / В. П.Захаров, И. А Братченко // Компьютерная оптика. – 2008. – Т. 32. – № 4. – С. 370 – 375.
  14. Mackie, R. M. Incidence and thickness of primary tumors and survival of patients with cutaneous malignant melanoma in relation to socioeconomic status [Текст] / R. M. Mackie, D. J. Hole // BMJ. – 1996. – Vol.312. – С. 1125 – 1128.
  15. Sterenborg, H. In vivo fluorescence spectroscopy and imaging of human skin tumors [Текст] / H.Sterenborg, M. Motamedi, R. F. Wagner, M. Duvic, S. Thomsen, S. L. Jacques // Lasers Med Sci. – 1994. - No9. – С. 191 – 201.
  16. Tuchin V. V. Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis // SPIE Tutorial Text in Optical Engineering, – 2000. – V2. – TT38.
  17. Jacques, S. L. Origins of tissue optical properties in the UVA, Visible and NIR regions // Advances in optical imaging and photon migration – 1996. – V2. – С. 364 – 369.
  18. Eikje, N. S. Vibrational spectroscopy for molecular characterisation and diagnosis of benign, premalignant and malignant skin tumors [Текст] / N. S. Eikje, K. Aizawa, Y. Ozaki // Biotechnol Annu Rev. – 2005. No11. – С. 191 – 225.
  19. Gniadecka, M. Melanoma Diagnosis by Raman Spectroscopy and Neural Networks: Structure Alterations in Proteins and Lipids in Intact Cancer Tissue [Текст] / M. Gniadecka, P. A. Philipsen, S. Sigurdsson, S. Wessel, O. F. Nielsen, D. H. Christensen, J. Hercogova, K.Rossen, H. K. Thomsen, R. Gniadecki, L. K. Hansen, and H. C. Wulf // J. Invest. Dermatol. – 2004. – Vol 122. – С. 443 – 449.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 VESTNIK of the Samara State Aerospace University

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies