Increasing the information content of optical coherence tomography skin pathology detection

Abstract

A mathematical model of optical radiation interaction with skin tissues is constructed, which takes into account the effects of stimulated Raman scattering. On the basis of numerical experiments the features in the Raman scattering spectra are revealed to characterize skin abnormalities. The possibility of significant increase in information content for optical coherence tomography and Raman spectroscopy joint usage is shown. Recent improvement is achieved by significantly reducing the volume of diagnostic measurements during the tissue layers isolation with the help of OCT, followed by their analysis by Raman spectroscopy. Differences in Raman scattering intensities for abnormal and normal tissue layers are established, their values may differ by an amount of 40%.

About the authors

V. P. Zakharov

Samara State Aerospace University

Author for correspondence.
Email: zakharov@ssau.ru

Doctor of Physical and Mathematical Sciences

Professor

Head of the Radioengineering Devices Department

Russian Federation

K. Larin

University of Houston (USA)

Email: klarin@uh.edu

Professor

Director of Biomedical Optics Laboratory

United States

I. A. Bratchenko

Samara State Aerospace University

Email: ud_liche@mail.ru

Assistant of the Radioengineering Devices Department

Russian Federation

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