GENETIC POLYMORPHISM OF GENES ASSOCIATED WITH VIRULENCE IN MYCOBACTERIUM TUBERCULOSIS STRAINS FROM SAMARA REGION


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Abstract

The prevalence of polymorphisms in Mycobacterium tuberculosis genes associated with virulence as well as its associations with genetic groups, clusters of strains and drug susceptibility was investigated in the article. The associations between polymorphisms in plcA gene and some LAM family clusters, dosT and pks15/1 genes and Beijing family and lipR gene and the majority of Ghana, Cameroon, Uganda and S clusters were found. Detected interrelation between studiedpolymorphisms and drug susceptibility is of mediated character.

About the authors

I.S. Kontsevaya

Samara State University

Author for correspondence.
Email: morenov.sv@ssau.ru

O.N. Makurina

Samara State University

Email: morenov.sv@ssau.ru

V.V. Nikolayevskyy

Queen Mary’s College,University of London

Email: morenov.sv@ssau.ru

References


Copyright (c) 2017 И.С. Концевая, О.Н. Макурина, В.В. Николаевский

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