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GENETIC POLYMORPHISM OF GENES ASSOCIATED WITH VIRULENCE IN MYCOBACTERIUM TUBERCULOSIS STRAINS FROM SAMARA REGION
- Authors: Kontsevaya I.1, Makurina O.1, Nikolayevskyy V.2
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Affiliations:
- Samara State University
- Queen Mary’s College,University of London
- Issue: Vol 20, No 3 (2014)
- Pages: 178-186
- Section: Articles
- URL: https://journals.ssau.ru/est/article/view/4583
- DOI: https://doi.org/10.18287/2541-7525-2014-20-3-178-186
- ID: 4583
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Abstract
The prevalence of polymorphisms in Mycobacterium tuberculosis genes associated with virulence as well as its associations with genetic groups, clusters of strains and drug susceptibility was investigated in the article. The associations between polymorphisms in plcA gene and some LAM family clusters, dosT and pks15/1 genes and Beijing family and lipR gene and the majority of Ghana, Cameroon, Uganda and S clusters were found. Detected interrelation between studiedpolymorphisms and drug susceptibility is of mediated character.
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About the authors
I.S. Kontsevaya
Samara State University
Author for correspondence.
Email: morenov.sv@ssau.ru
O.N. Makurina
Samara State University
Email: morenov.sv@ssau.ru
V.V. Nikolayevskyy
Queen Mary’s College,University of London
Email: morenov.sv@ssau.ru
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