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PRODUCTION OF PEPTIDE COMPOUNDS IN HUMAN ERYTHROCYTES AT HYPERGLYCEMIA AND THEIR EFFECT ON THE PROTEOLYTIC ACTIVITY OF LEUKOCYTE
- Authors: Vasilieva S.1, Mochalova E.1, Isaeva A.1, Klenova N.1
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Affiliations:
- Samara State University
- Issue: Vol 19, No 9.1 (2013)
- Pages: 128-133
- Section: Articles
- URL: https://journals.ssau.ru/est/article/view/4694
- DOI: https://doi.org/10.18287/2541-7525-2013-19-9.1-128-133
- ID: 4694
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Abstract
An increase in the production of peptide compounds in human erythrocytes incubated by them in conditions of hyperglycemia (10 mmol/L) compared with normoglycemia (5 mmol/L) is found. At that the spectrum of peptide compounds changes, since a change of their action on the activity of cathepsin D leukocytes: in normoglycemia allocated erythrocytes peptides increase the activity of cathepsin D with calcium deficiency in the environment, and in conditions of hyperglycemia, on the contrary inhibit the enzyme in the presence of calcium ions.
About the authors
S.G. Vasilieva
Samara State University
Author for correspondence.
Email: morenov.sv@ssau.ru
E.P. Mochalova
Samara State University
Email: morenov.sv@ssau.ru
A.V. Isaeva
Samara State University
Email: morenov.sv@ssau.ru
N.A. Klenova
Samara State University
Email: morenov.sv@ssau.ru
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