EFFECT OF PHENOLIC DERIVATIVES OF BENZIMIDAZOLE ON GROWTH AND ENZYME ACTIVITY OF E. COLI

Dose-response stady (concentration of 50-200 mkg/ml) effect on growth total degidrogenase, catalase, sukcinatdegidrogenase activity of E. COLI phenolic benzimidazole derivatives containing a methyl group and the glycoside radical is researched. All compounds have dozo-respouse bacteriostatic effect and cause metabolic stress, resulting in higher concentrations of active degidrogenase and catalase. Most damaging effect has 4(2-methyl-1fi-benzimidazol-ylmethyl)phenyl-2,3,4,6-tetra-O-azethyl-/3-D-glucopyranozyd in a concentration of 200 mkg/ml.

phenolic benzimidazole derivates, E.coli, growth and enzyme activity