Proceedings of young scientists and specialists of the Samara UniversityProceedings of young scientists and specialists of the Samara University2782-2982Samara National Research University9213Research ArticleINFLUENCE OF N - ACETYLGLYCINE AND ITS PRECURSOR ON ISOLATED FROGS HEARTNikonovSergey Nikolaevichwolfgtm3@rambler.ruZaynulinRuslan Anasovichzajnulin63@inbox.ruRomanovaIrina Dmitrievnaromanova_id@mail.ruSamara University151120191 (14)879222082021Copyright © 2019, Proceedings of young scientists and specialists of the Samara University2019This article shows the effect of the precursor of the studied compound glycine on such parameters as heart rate, stroke volume of the heart, minute volume of the heart and the effect on compliance with Frank-Starling law. The study of glycine revealed similar, but more pronounced increase in the minute volume of the heart and heart rate. Effective concentrations for both substances were 10-6 M and 10-4 M. The article discusses the possibility of using N-acetylglycine as a safer diagnostic fluid for endoscopic heart operations.глициновый рецептормиокардзакон Франка - Старлингаglycine receptormyocardiumFrank-Starling law[Сергеев П. В., Шимановский Н. Л., Петров В. И. Рецепторы физиологически активних веществ. Волгоград: Семь ветров, 1999. 640 с.][Qi R. B., Zhang J. Y. Glycine receptors contribute to cytoprotection of glycine in myocardial cells // Chinese medical journal. 2007. Vol. 120. № 10. P. 915-921.][Wang H. D., Lu D. X. Glycine inhibits the LPS-induced increase in cytosolic Ca2+ concentration and TNFalpha production in cardiomyocytes by activating a glycine receptor // Acta Pharmacologica Sinica. 2009. Vol. 30. № 8. P. 1107-1114.][Lynch J. W. Molecular structure and function of the glycine receptor chloride channel // Physiological reviews. 2004. Vol. 84. № 4. Р. 1051-1059.][Судаков К. В. Нормальная физиология. М.: МИА, 2006. 921 с.]