Proceedings of young scientists and specialists of the Samara UniversityProceedings of young scientists and specialists of the Samara University2782-2982Samara National Research University8552Research ArticleFEATURE ESTROUS CYCLE IN RATS AND VALUE KISSPEPTINERGIC SYSTEM IN ITS REGULATIONLoktaevaAnastasiya Vladimirovnavodoleys@mail.ruBelyakovVladimir Ivanovichvladbelakov@mail.ruSamara University151220162 (9)323808042021Copyright © 2016, Proceedings of young scientists and specialists of the Samara University2016In the model experiment on adult female rats were studied features of the estrous cycle, analyzed cytological picture of vaginal smears in the individual stages of the cycle (proestrus, estrus, diestrus). Marked change in the various indices kalpotsitogrammy at stages of the estrous cycle. The paper summarizes information about the significance of the components kisspeptinergic system to ensure the functioning of the hormonal axis «hypothalamus-anterior pituitary-ovarian».эстральный циклэcтруcпроэструсдиэструскисспептин[Бабичев В. Н. Нейроэндокринная регуляция репродуктивной системы. Пущино: ОНТИ ПНЦ РАН, 1995. 227 с.][Babiker A., Al Shaikh A. The role of kisspeptin signalling in control of reproduction in genetically similar species. Sudan // J. Paediatr. 2016. Vol. 16 (1). P. 9-16.][Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons / S. Constantin, C. S. Caligioni, S. Stojilkovic [et al.] // Endocrinology. 2009. Vol. 150. P. 1400-1412.][Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 / N. De Roux, E. Genin, J. C. Ca-rel [et al.] // Proc. Natl. Acad. Sci. 2003. Vol. 100. P. 10972-10976.][The GPR54 gene as a regulator of puberty / S. B. Seminara, S. Messager, E. E. Chatzidaki [et al.] // The New England Journal of Medicine. 2003. Vol. 349. P. 1614-1627.][Алексеев Б. Е., Белоус И. М. Сексуальные дисфункции у женщин с психогенными депрессиями // Обозрение психиатрии и медицинской психологии. 2013. № 1. С. 22-24.][Перехов А. Я. Депрессия и сексуальные расстройства у женщин в естественной и хирургической менопаузе // ОРЖИН. Акушерство. Гинекология. Репродукция. 2009. № 4. C. 6-9.][Wise P. M., Kashon M. L., Krajnak K. M. Aging of the female reproductive system: a window into brain aging // Recent Prog. Horm. Res. 1997. Vol. 52. P. 279-303.][Cora M. C., Kooistra L., Travlos G. Vaginal Cytology of the Laboratory Rat and Mouse: Review and Criteria for the Staging of the Estrous Cycle Using Stained Vaginal Smears // Toxicol. Pathol. 2015. Vol. 43 (6). Р. 776-793.][Chen W. P., Witkin J. W., Silverman A. J. Gonadotropin releasing hormone (GnRH) neurons are directly innervated by catecholamine terminals // Synapse. 1989. Vol. 3 (3). P. 288-290.][Horvath T. L., Naftolin F., Leranth C. Luteinizing hormone-releasing hormone and gamma-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior periventricular areas // J. Neuroendocrinol. 1993. Vol. 5 (1). P. 71-79.][Role of classic and peptide neuromediators in the neuroendocrine regulation luteinizing hormone and prolactine / C. Kordon, S. V. Drouva, G. M. de la Escalera [et al.] // The physiology of reproduction. NY.: Raven Press Ltd, 1994. P. 1621-1681.][Herbison A. E. Noradrenergic regulation of cyclic GnRH secretion // Rev. Reprod. 1997. Vol. 2 (1). P. 1-6.][Роль биогенных аминов в гипоталамической регуляции репродуктивной функции / А. В. Арутюнян, Г. О. Керкешко, М. Г. Степанов [и др.] // Журнал акушерства и женских болезней. 2004. Вып. LIII (1). С. 98-106.][Зарубина Е. Г., Лысова А. Н., Беляков В. И. Влияние kiss-пептина на эстральный цикл крыс // Морфологические ведомости. 2014. № 2. С. 34-40.][Ohtaki T., Shintani Y., Honda S. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor // Nature. 2001. Vol. 411. P. 613-617.][Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor / L. J. Stafford, C. Xia, W. Ma [et al.] // Cancer Research. 2002. Vol. 62. P. 5399-5404.][Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge / J. Clarkson, X. d'Anglemont de Tassigny, A. S. Moreno [et al.] // J. Neurosci. 2008. Vol. 28 (35). P. 8691-8697.]