STATE SYSTEM OF HEMOGLOBIN AND THE ACTIVITY OF ENZYMES OF HUMAN ERYTHROCYTES UNDER CONDITIONS OF HYPERGLYCEMIA IN VITRO



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Abstract

The study of condition of the system of hemoglobin, release of peptide com- pounds, and proteolytic activity of human erythrocytes under conditions of hy- perglycemia of varying degrees is carried out. The increase in the level of hy- perglycemia is accompanied by a decrease of affinity of hemoglobin to oxygen and the growth of level of metgemoglobin, the glycosylated hemoglobin level is increased in conditions of severe hyperglycemia. The level of formation of pep- tides in erythrocytes and the level of output of their cells is determined by the increase in trypsin-like activity in cytosol and increased membrane permeability of red blood cells.

About the authors

A.A. Panarina

Samara State University

Author for correspondence.
Email: morenov.sv@ssau.ru

A.A. Pestryakova

Samara State University

Email: morenov.sv@ssau.ru

A.V. Sadychova

Samara State University

Email: morenov.sv@ssau.ru

N.A. Klenova

Samara State University

Email: morenov.sv@ssau.ru

E.A. Lebedeva

Samara State Medical Univesity

Email: morenov.sv@ssau.ru

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Copyright (c) 2015 Panarina A., Pestryakova A., Sadychova A., Klenova N., Lebedeva E.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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